Inter-day Reliability of the Oral Glucose Tolerance Test Using Indirect Calorimetry
试验速览
- 阶段
- 不适用
- 入组人数
- 20
- 试验地点
- 2
- 主要终点
- Inter-day reliability, 7 days apart, in post-prandial nutrient oxidation
研究概览
简要总结
The main aim of this study is to determine the inter-day reliability, by using indirect calorimetry, of the post-prandial macronutrient oxidation and energy expenditure after consuming oral glucose load solution.
详细描述
The maintenance of blood glucose concentrations and the oxidation of carbohydrate after consuming carbohydrate is related with a low risk of mortality and morbidity from cardiometabolic diseases. The oral glucose tolerance test is a diagnostic test widely used in the clinical field. However, its inter-day reliability has not been deeply studied. Therefore, it is of clinical interest to study the inter-day reliability of the diagnostic test oral glucose tolerance test using indirect calorimetry and monitoring the response of the glucose levels.
20 young adults will undergo two trials visit with 7 days of separation between conditions. Each evaluation day will conform to the following tests:
- Basal metabolic rate assessment through indirect calorimetry.
- Basal heart rate variability through heart rate monitor.
- Intake of the corresponding glucose load solution.
- Postprandial nutrient oxidation and energy expenditure assessment through indirect calorimetry
- Glucose monitoring through Glucose meter.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Other
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy male or female
- •Ages 18-30 years
- •BMI: 18-27.5 kg/m2
- •Stable weight over the last 3 months (body weight changes<35kg)
- •Participant must be capable and willing to provide consent, understand exclusion criteria, instructions and protocols.
排除标准
- •History of cardiovascular disease
- •Diabetes or hypertension
- •Pregnant, planning to become pregnant, or breastfeeding
- •Have been treated previously or during the study period with prescription drugs: antihypertensive, lipid lowering, acid uric lowering, glucose lowering, beta blockers or any drug that under the investigator's judged could influence the results.
- •Any non-controlled medical condition which could influence results or could be worsened by the participation in the study.
- •Claustrophobia
- •Needle phobia
- •Are deemed unsuitable by the investigator for any other reason, that prevent data collection.
结局指标
主要结局
Inter-day reliability, 7 days apart, in post-prandial nutrient oxidation
时间窗: 7 days
Reliability
次要结局
- Inter-day reliability, 7 days apart, in post-prandial energy expenditure(7 days)
- Inter-day reliability, 7 days apart, in glucose levels(7 days)
研究者
Jonatan Ruiz Ruiz
Associate professor
Universidad de Granada