A Study on Integrated Multi-Omics and Multi-Factor Analysis of Peripheral Blood in Patients With Acute Coronary Syndrome
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 310
- 试验地点
- 1
- 主要终点
- circulating fibroblast growth factors (FGFs) levels
研究概览
简要总结
The goal of this study is to conduct analyses the changes of cell growth factors, inflammatory factors, metabolites, plasma proteome, etc. in the blood of patients with ACS (acute coronary syndrome), as well as their correlations with the disease prognosis, based on multi-omics or other related research methods. The main questions it aims to answer are:
The growth factors that have significant changes in the peripheral blood of the ACS population, especially fibroblast growth factors? Inflammatory factors and chemokines related to the onset of ACS? The metabolites and proteins that are significantly altered in the peripheral blood after the onset of ACS? Researchers will compare ACS population to CCS (Chronic Coronary Syndrome) population, and control group (patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy).The peripheral venous blood from the participants will be collected within 24 hours after their admission to the hospital.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •For ACS group STEMI
- •cTn>99th ULN or CK-MB>99th ULN
- •ST-segment elevation with a convex upward morphology
- •in conjunction with one or more of the following conditions: persistent ischemic chest pain; echocardiographic evidence of abnormal segmental ventricular wall motion; or abnormal coronary angiography findings.
- •cTn>99th ULN or CK-MB>99th ULN
- •accompanied by one or more of the following situations: persistent ischemic chest pain; new ST-segment depression or low and inverted T waves; echocardiography showing segmental ventricular wall motion abnormalities; abnormal coronary angiography.
- •cTn normal
- •ischemic chest pain with an electrocardiogram showing transient ST-segment depression or flattened and inverted T waves
- •evidence of coronary artery stenosis (e.g., CTA demonstrating ≥ 50% stenosis) For CCS group
- •Clinical Diagnosis Consistent with CCS Categories, meet any one of the following clinical scenarios: Stable Angina Pectoris, Ischemic Cardiomyopathy, Post-ACS Stable Phase, Long-Term CAD Management, Vasospastic or Microvascular Disease, Asymptomatic CAD
- •Laboratory and Imaging Confirmation: Resting ECG without ST-segment elevation or dynamic changes (excluding ACS), cTn normal or stable (no acute myocardial injury), ≥50% luminal stenosis in ≥1 epicardial coronary artery For control group
- •Patients without coronary artery stenosis, valvular heart disease, structural heart disease, or any other kind of cardiomyopathy
排除标准
- •Lactating or pregnant women
- •Patients with malignant neoplasms
- •Severe hepatic/renal dysfunction
- •Severe hematological disorders
- •Autoimmune diseases
结局指标
主要结局
circulating fibroblast growth factors (FGFs) levels
时间窗: within 24 hours of admission to the hospital
examining the circulating fibroblast growth factors levels in the peripheral venous blood of the participants
circulating inflammatory cytokines levels
时间窗: within 24 hours of admission to the hospital
examining the circulating inflammatory cytokines levels in the peripheral venous blood of the participants
circulating chemokines levels
时间窗: within 24 hours of admission to the hospital
examining the circulating chemokines levels in the peripheral venous blood of the participants
circulating Cytochrome C level
时间窗: within 24 hours of admission to the hospita
examining the circulating cytochrome c levels in the peripheral venous blood of the participants
circulating mitochondrial DNA levels
时间窗: within 24 hours of admission to the hospital
examining the circulating mitochondrial DNA levels in the peripheral venous blood of the participants
circulating malondialdehyde levels
时间窗: within 24 hours of admission to the hospital
examining the circulating malondialdehyde levels in the peripheral venous blood of the participants
次要结局
- the relationship between FGFs/inflammatory cytokines/chemokines and troponin I (TnI)(within 24 hours of admission to the hospital)
- the relationship between FGFs/inflammatory cytokines/chemokines and brain natriuretic peptide (BNP)(within 24 hours of admission to the hospital)
- the relationship between FGFs/inflammatory cytokines/chemokines and lactate dehydrogenase (LDH)(within 24 hours of admission to the hospital)
- the relationship between FGFs/inflammatory cytokines/chemokines and left ventricular ejection fraction (LVEF)(within 24 hours of admission to the hospital)
- the relationship between FGFs/inflammatory cytokines/chemokines and mitochondrial DNA (mitoDNA)(within 24 hours of admission to the hospital)
- the relationship between FGFs/inflammatory cytokines/chemokines and cytochrome c(within 24 hours of admission to the hospital)
- the relationship between FGFs/inflammatory cytokines/chemokines and malondialdehyde(within 24 hours of admission to the hospital)