Pharmacokinetics of Meropenem During High-dose Continuous Renal Replacement Therapy in Critically Ill Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 19
- 试验地点
- 1
- 主要终点
- Plasma concentration of meropenem
研究概览
简要总结
Assessment of meropenem plasma concentration in critically ill patients who require CRRT (continuous renal replacement therapy). A standard dose of meropenem is administered, i.e. 1 gram every 8 hours.
详细描述
This is a prospective observational study performed on critically ill patients. Inclusion criteria are a severe infection on admission requiring the use of meropenem and CRRT.
Both medical and surgical patients will be included. Any type of infections can be included (pulmonary, abdominal, urinary tract, etc.) Antibiotics regimen includes one-hour infusion of meropenem (1.0 gram) intravenously every 8 hours.
Blood samples (2 mL) will be collected at the 15, 30, 45, 60, 75, 90, 120, 180, 240, and 480 minutes after each dose of meropenem for 3 consecutive days. The standard arterial canula will be used to obtain samples.
30 minutes after each sample collection, blood will be centrifuged for 10 minutes at 3,000 rpms. Subsequently, supernatant will be collected and frozen.
Serum meropenem concentration will be measured by high-performance liquid chromatography.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients who require ICU treatment due to severe infection
- •age 18-80 years
- •an eligible consent obtained from the patient or his/her attendant
排除标准
- •allergy to meropenem
- •lack of consent to participate in the study
- •age of patients below 18 or above 80 years
研究组 & 干预措施
Meropenem
Patients who require meropenem and CRRT during ICU (intensive care unit) stay
干预措施: Meropenem (Drug)
Meropenem
Patients who require meropenem and CRRT during ICU (intensive care unit) stay
干预措施: CRRT (Device)
结局指标
主要结局
Plasma concentration of meropenem
时间窗: 3 days
次要结局
未报告次要终点
研究者
Michał Borys
M.D., Ph.D.
Medical University of Lublin