A Prospective Randomized Trial for the Use of DDAVP in the Reduction of Post-operative Ecchymosis in Rhinoplasty.
试验速览
- 阶段
- 2 期
- 状态
- 终止
- 入组人数
- 14
- 试验地点
- 1
- 主要终点
- Reduction in Ecchymosis and Swelling
研究概览
简要总结
This is study looking at the use of a medication, Desmopressin acetate (DDAVP), to reduce bleeding, swelling, and bruising in patients undergoing cosmetic nose surgery. DDAVP is a drug used in patients with bleeding disorders. It works by activating molecules in the blood stream called platelets that promote clotting. In the study, participants who are have cosmetic nose surgery (rhinoplasty) will be randomly assigned to receive or not receive medication. Photographs taken before and shortly after surgery will be evaluated for the amount of bruising and swelling. Patients with heart, lung, kidney, or liver problems are not eligible to participate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Undergoing Rhinoplasty where nasal bone osteotomy is necessary
排除标准
- •Heart Disease
- •Renal Disease with decreased GFR
- •Liver Disease
研究组 & 干预措施
DDAVP
Arm receiving DDAVP prior to the operation. Drug is administered intravenously at .3mcg per kg, over 30 minutes prior to the operation.
干预措施: DDAVP (Drug)
结局指标
主要结局
Reduction in Ecchymosis and Swelling
时间窗: surgery to 8 days post-operatively
Photographs taken preoperatively at 1 day and 8 days post-operatively will be analyzed for bruising
次要结局
- Patient Behavior Factors(Surgery to 3 weeks post-operatively)