Supplementary Oxygen in Surgical and Medical Wards in the Capital Region of Denmark Evaluated by 30-day Mortality, a Retrospective Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 11,196
- 试验地点
- 1
- 主要终点
- 30- day mortality
研究概览
简要总结
This study evaluates the use and effects of supplementary oxygen in surgical and medical wards on patients admitted to a hospital in the capital region of Denmark. The population will be divided in to three groups according to their oxygenation status. The main outcome will be 30-day mortality, with secondary outcomes being Length of stay, 30-day admission to ICU, 30-day reoperations, 30-day readmission, and peak values within 30-days of C-reactive protein, S-Creatinine, Troponin.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Admission date between 1st of January 2014 to 29th of December 2014 on a hospital in the capital region of Denmark
- •Unique (first) admission in database for either:
- •Hip fracture requiring surgery
- •Chronic obstructive pulmonary disease in exacerbation
- •Acute mycardial infarction
- •Open abdominal surgery
排除标准
- •No data on saturation within 48 hours after
- •Admission (Medical patients)
- •Discharge from the post anaesthesia care unit (Surgical patients)
- •No data on primary outcome (30-day mortality)
研究组 & 干预措施
Hypoxia
Patients without chronic obstructive pulmonary disease: blood oxygen saturation <94 % irrespective of supplemental oxygen
Patients with chronic obstructive pulmonary disease: blood oxygen saturation <88% irrespective of supplemental oxygen
干预措施: Oxygen gas (Drug)
Normoxia
Patients without chronic obstructive pulmonary disease: blood oxygen saturation 94-98% in combination with supplemental oxygen OR blood oxygen saturation ≥94% without supplemental oxygen.
Patients with chronic obstructive pulmonary disease: blood oxygen saturation 88-92% in combination with supplemental oxygen OR blood oxygen saturation ≥88% without supplemental oxygen.
干预措施: Oxygen gas (Drug)
Hyperoxia
Patients without chronic obstructive pulmonary disease: blood oxygen saturation >98% in combination with supplemental oxygen
Patients with chronic obstructive pulmonary disease: blood oxygen saturation >92% in combination with supplemental oxygen
干预措施: Oxygen gas (Drug)
结局指标
主要结局
30- day mortality
时间窗: 30 days
Will be reported as a fraction of positives within the exposure group population
次要结局
- 30- day readmission(30 days)
- Organ markers in blood samples(30 days)
- 30- day admission to ICU(30 days)
- Length of stay(30 days)
研究者
Hannibal Troensegaard
Primary investigator
University Hospital Bispebjerg and Frederiksberg