Optimizing Hand Rehabilitation Post-Stroke Using Interactive Virtual Environments
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 55
- 试验地点
- 1
- 主要终点
- Change in Jebsen Test of Hand Function
研究概览
简要总结
The complexity of sensorimotor control required for hand function as well as the wide range of recovery of manipulative abilities makes rehabilitation of the hand most challenging. The investigators past work has shown that training in a virtual environment (VE) using repetitive, adaptive algorithms has the potential to be an effective rehabilitation medium to facilitate motor recovery of hand function. These findings are in accordance with current neuroscience literature in animals and motor control literature in humans. The investigators are now in a position to refine and optimize elements of the training paradigms to enhance neuroplasticity. The investigators first aim tests if and how competition among body parts for neural representations stifles functional gains from different types of training regimens. The second aim tests the functional benefits of unilateral versus bilateral training regimens.The third aim tests whether functional improvements gained from training in a virtual environment transfer to other (untrained) skills in the real world.
详细描述
The complexity of sensorimotor control required for hand function as well as the wide range of recovery of manipulative abilities makes rehabilitation of the hand most challenging. The investigators past work has shown that training in a virtual environment (VE) using repetitive, adaptive algorithms has the potential to be an effective rehabilitation medium to facilitate motor recovery of hand function. These findings are in accordance with current neuroscience literature in animals and motor control literature in humans. The investigators are now in a position to refine and optimize elements of the training paradigms to enhance neuroplasticity. The investigators first aim tests if and how competition among body parts for neural representations stifles functional gains from different types of training regimens. The second aim tests the functional benefits of unilateral versus bilateral training regimens.The third aim tests whether functional improvements gained from training in a virtual environment transfer to other (untrained) skills in the real world.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Six months post cerebrovascular accident
- •Residual upper extremity impairment that affects participation
- •At least ten degrees of active finger extension
- •Tolerate passive shoulder flexion to chest level
排除标准
- •Severe neglect
- •Severe aphasia
研究组 & 干预措施
Train Paretic Hand and Arm Separate
Eight three hour training sessions of robotically facilitated hand and arm training in complex virtual environments, using activities that train the fingers in isolation and other activities that train the arm in isolation.
干预措施: HAS Training (Behavioral)
Train Paretic Hand and Arm Together
干预措施: HAT training (Behavioral)
Train Both Hands Together in VE
干预措施: Bimanual Training (Behavioral)
结局指标
主要结局
Change in Jebsen Test of Hand Function
时间窗: Two Weeks Prior to Training, Immediately Prior to Training, Immediately After Training, 3 Months After Training
次要结局
- Change in Box and Blocks Test(Two Weeks Prior to Training, Immediately Prior to Training, Immediately After Training, 3 Months After Training)
- Change in Robotically Collected Kinematics(1 day before training and 1 day after training)
- Change in Wolf Motor Function Test(Two Weeks Prior to Training, Immediately Prior to Training, Immediately After Training, 3 Months After Training)
- Change in Reach to Grasp Test(1 day before training and 1 day after training)
- Change in 9 Hole Peg Test(Two Weeks Prior to Training, Immediately Prior to Training, Immediately After Training, 3 Months After Training)
研究者
Sergei V. Adamovich PhD
Associate Professor
New Jersey Institute of Technology