the Clinical Research Using Simvastatin as a Medication to Treat Advanced Secondary Pulmonary Hypertension
试验速览
- 阶段
- 1 期
- 发起方
- 试验地点
- 1
- 主要终点
- the simvastatin can alleviate pulmonary hypertension
研究概览
简要总结
we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
详细描述
advanced pulmonary hypertension is refractory to the medication in use nowaday, especially pulmonary hypertension secondary to congenital heart disease or chronic pulmonary embolism.It is revealed that statins may intefere the pathogenisis of the pulmonary hypertension in many key poing, such as improving apotosis or inhiting the proliferation of pulmonary vascular smooth muscle cell. so we try to use simvastatin in the treatment of advanced pulmoary hypertension secondary to congenital heart disease or chronic pulmonary embolism before and after the operation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 12 Years 至 70 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •pasp>50mmHg
排除标准
- •pasp<50mmhg
研究组 & 干预措施
1simvastatin group
before the operation, the patient start the simvastatin medication on the dosage of 40mg per day
干预措施: simvastatin (Drug)
结局指标
主要结局
the simvastatin can alleviate pulmonary hypertension
pulmonary pressure
次要结局
- simvastatin can highten the perioperative and long term survaval rate and the living quality