What is the Incidence of an Immune Disorder in Children With Invasive Pneumococcal Disease (IPD)? A Prospective Cohort Study.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 380
- 试验地点
- 6
- 主要终点
- types of immunodeficiency associated with children who present with invasive pneumococcal disease
研究概览
简要总结
This is a multicentre prospective audit to determine the incidence of immunodeficiency in children with IPD.
Aims and/or research question of the project
- To determine the incidence of primary immunodeficiency in children >2 years who present with IPD
- To determine the types of immunodeficiency associated with IPD in children
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 0 Months 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Children aged 0 to 18 years admitted to one of the six centres with IPD.
排除标准
- •Children who do not fulfil the age criteria for immunological evaluation at that particular site e.g. aged <2 years at Royal Children's Hospital.
- •Children with a known underlying condition predisposing to IPD i.e. nephrotic syndrome.
结局指标
主要结局
types of immunodeficiency associated with children who present with invasive pneumococcal disease
时间窗: 3 years
This will be determined based on the testing performed by the immunologists.
incidence of primary immunodeficiency in children who present with invasive pneumococcal disease
时间窗: 3 years
This will be picked up upon prospective immunological testing, after identification of patients with invasive pneumococcal disease. A series of tests will be performed depending on the clinical opinion of the immunology team. Such tests may include lymphocyte subsets, complement function, serum immunoglobulin levels, memory B cells, vaccine antibody responses, etc.
次要结局
- whether increased referrals of children who present with invasive pneumococcal disease for investigation of primary immunodeficiency facilitates early detection(3 years)