NCT04466566已完成3 期
Effect of Genetic Variation in the GLP-1 Receptor on Beta-cell Function During Fasting and Hyperglycemia in Nondiabetic Humans
适应症
干预措施
相关药物
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 发起方
- Adrian Vella
- 入组人数
- 21
- 试验地点
- 1
- 主要终点
- Insulin secretion quantified using the minimal model to generate an index of beta-cell responsivity (Φ)
研究概览
简要总结
The GLP-1 receptor (GLP1R) gene is found on the beta cells of the pancreas. Its role is in the control of blood sugar level by enhancing insulin secretion from the pancreas after eating a meal. The purpose of this research study to find out how genetic variations in GLP1R alter insulin secretion, in the fasting state and when blood sugars levels are elevated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 25 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •40 nondiabetic subjects will be recruited.
- •20 subjects with the AA genotype at rs3765467 and remainder will have the GG genotype.
- •Individuals encompassing the age span of 25-65 years.
排除标准
- •Individuals under 25 and over 65 years of age.
研究组 & 干预措施
Saline
Placebo Comparator
Saline will be infused during the study
干预措施: Saline (Other)
Exendin-9,39
Active Comparator
Exendin-9,39 will be infused during the study
干预措施: Exendin-9,39 (Biological)
结局指标
主要结局
Insulin secretion quantified using the minimal model to generate an index of beta-cell responsivity (Φ)
时间窗: This will be calculated from the 0-180 minute data of the study
次要结局
- Glucagon secretion measured by immunoassay(This will be averaged over the 0-180 minute data of the study)
研究者
研究点 (1)
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