Mannitol and Methacholine Responsiveness: Effects of Deep Inhalations
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 1
- 主要终点
- airway responsiveness (PD15) to inhaled mannitol
研究概览
简要总结
The study will compare the airway responses to two bronchoconstricting agents, mannitol and methacholine.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •stable controlled asthma
排除标准
- •pregnancy
- •use of asthma therapies other than bronchodilator therapy
研究组 & 干预措施
Methacholine (Provocholine) with deep inhalation
干预措施: Methacholine (Provocholine) (Drug)
Mannitol (Aridol)
干预措施: Mannitol (Aridol) (Drug)
Methacholine (Provocholine) tidal breathing
干预措施: Methacholine (Provocholine) (Drug)
结局指标
主要结局
airway responsiveness (PD15) to inhaled mannitol
时间窗: Visit 2 = up to 13 days
The PD15 to mannitol will be captured once at either visit 2 or visit 3.
Airway responsiveness (PC20) to methacholine delivered over two minutes of tidal breathing
时间窗: Visit 1 (Day 1)
The two minute tidal breathing PC20 with be captured once at visit 1.
Airway responsiveness (PC20) to deep inhalation methacholine
时间窗: Visit 3 = up to 14 days
The PC20 to methacholine (deep inhalation) will be captured once at either visit 2 or visit 3.
次要结局
未报告次要终点
研究者
Don Cockcroft
Professor, College of Medicine
University of Saskatchewan