TCTR20210801005已完成1 期
AT 2 genotype-guided INH dosage for tuberculosis treatment to reduce antituberculosis drug-induced liver injury in Thai patients
Department of medical services, Ministry of Public Health of Thailand0 个研究点目标入组 10 人开始时间: 2021年8月1日最近更新:
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 10
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 Years 至 90 Years（—）
- 性别
- All
入选标准
- •1. Age more than 18 years
- •2. Newly diagnosed pulmonary tuberculosis
- •3. Slow acetylator phenotype
- •4. Provided written informed consent
排除标准
- •1) liver cirrhosis child pugh C; 2) alcoholism or alcohol drinking 14 days before enrollment abnormal liver function test at baseline; alanine aminotransferase (ALT) or aspartate aminotransferase (AST) >3 times the upper limit of normal (ULN); 3) herbal medicine used; 4)HIV infection; 5) Chronic kidney disease define as eGFR < 30; 6) severe tuberculosis with high risk of poor outcome e.g., acute respiratory failure; 7) any conditions that may contribute unfavorable outcome; 8) life-threatening condition such as sepsis, respiratory failure, congestive heart failure; 9) body weight < 35 Kg and > 80 Kg; 10) pregnant and lactating woman.
研究者
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