Gene Expression Profiles in Chronic Periodontitis: A Gene Network-based Microarray Analysis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 46
- 主要终点
- mRNA quantification
研究概览
简要总结
Current concepts of the causes of periodontitis implicate a bacterial infection as the primary cause of the disease. Several bacterial species residing in a biofilm on tooth surfaces are closely associated with periodontitis. Chronic periodontitis (CP) is initiated and sustained by bacterial plaque, but host defense mechanisms play an integral role in its pathogenesis.
Gene expression profiling is a powerful means of generating comprehensive genome-level data sets on diseases such as cancer, asthma, rheumatoid disorders and periodontitis, and provides significant insight information for these diseases. Gene expression profiling may provide an evidence for involving genes in the pathogenesis of CP and generate further information other than clinical signs and symptoms of CP.
The aim of this study was to identify gene-expression patterns of patients with chronic periodontitis by whole-transcriptome gene-expression analyses.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •CP patients had at least 20 teeth exhibiting >30% of measured sites with >5mm clinical attachment loss.
- •Had bleeding on probing (BOP) at >50% of the proximal sites.
排除标准
- •Had any known systemic diseases that can influence the periodontal status, oral diseases other than chronic periodontitis and ongoing orthodontic therapy.
- •History of hepatitis, HIV infection, or diabetes; requirement for antibiotic prophylaxis, pregnancy or lactation; and long-term use of anti-inflammatory drugs.
- •Should be free of systemic diseases
- •Individuals had to be older than 18 years of age.
结局指标
主要结局
mRNA quantification
时间窗: 2 months
次要结局
- Gen networking map(2 months)
研究者
Esra Guzeldemir-Akcakanat
Associate Profesor
Kocaeli University