DM199 for Pregnancy Complications

Stellenbosch University0 个研究点目标入组 120 人开始时间: 2024年4月9日最近更新: 2024年4月29日

适应症

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•Severe complications of preeclampsia which include eclampsia, pulmonary edema, HELLP syndrome, severe renal involvement, cerebrovascular event is defined as an ischaemic or haemorrhagic stroke associated with clinical symptoms and definitive signs on imaging and or a liver haematoma or rupture
•Placental abruption
•Clinical infection eg. chorioamnionitis
•Underlying maternal cardiac disease including a significant arrhythmia, a conduction abnormality or severe valvular disease or congenital or acquired heart disease
•Significant maternal vascular disease eg. renal artery stenosis
•Patient is unable, or unwilling to give consent, or is under the age of 18.
•Suspicion or diagnosis of a major fetal anomaly or malformation or chromosomal abnormality. A major fetal anomaly is defined as anomalies or malformations that create significant medical problems for the neonate or that require specific surgical or medical management.
•Established fetal compromise that necessitates urgent delivery
•History of clinically significant allergic reactions such as angioedema or anaphylaxis requiring hospitalization or familial angioedema
•Participant is currently participating in or has participated in a study using an investigational device or drug or received an investigational drug or investigational use of a licensed drug within 30 days prior to screening
•Women with an active malignancy

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