Mindfulness Based Stress Reduction for Parkinson's Disease: A Longitudinal Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 107
- 试验地点
- 2
- 主要终点
- Parkinson's Disease Questionnaire-39
研究概览
简要总结
To investigate the efficacy of Mindfulness-based Stress Reduction (MBSR) to improve quality of life, cognition, and mood, as well as to determine the longevity of the treatment response in individuals with Parkinson's disease (PD).
详细描述
Eligible study participants with PD were randomly assigned to one of two 9-week remote (online) interventions: 1) Mindfulness Based Stress Reduction (MBSR) or 2) Psychoeducational Supportive Care (PSC). Intervention groups consisted of approximately 6-9 individuals and met weekly for 2.5 hours x 8 weeks and for 4 hours ("retreat") during week 7. All participants were remotely administered a battery of neuropsychological tests to measure quality of life, cognition (e.g., executive function, attention, memory), and mood (i.e., anxiety, depression, and apathy), as well as motor symptoms, disease severity, and mindfulness engagement/practice at pre-intervention (baseline), post-intervention (9 weeks), and at 6- and 12-months (follow-up assessments).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Investigator, Outcomes Assessor)
盲法说明
Investigator and Assessor are blinded to group assignment.
入排标准
- 年龄范围
- 40 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Clinical diagnosis of PD based on UK Brain Bank Criteria
- •40 years of age or older
排除标准
- •Secondary causes of Parkinsonism (e.g. corticobasal degeneration, progressive supranuclear palsy, drug-induced parkinsonism)
- •Other neurological conditions (e.g. stroke)
- •Clinical diagnosis of dementia based on any previous neuropsychological testing
- •Psychosis, antipsychotic treatment or treatment for substance abuse
- •Uncorrected vision or hearing to adequately participate in the intervention
- •Prior formal training in MBSR or regular current MBSR practice
- •Inability to use a computer or technology for participation
- •Active/current suicidal ideation
结局指标
主要结局
Parkinson's Disease Questionnaire-39
时间窗: pre- to post-intervention (0 to 9 weeks)
Parkinson's disease Quality of Life (PDQ-39); Total Score = 0-156; higher score = worse quality of life.
Parkinson's Disease Questionnaire-39
时间窗: pre- to post-intervention (0 to 9 weeks)
Parkinson's disease Quality of Life (PDQ-39); Total Score = 0-156; higher score = worse quality of life.
次要结局
- Matrix Reasoning Test(pre- to post-intervention (0 to 9 weeks))
- State-Trait Anxiety Inventory(pre- to post-intervention (0 to 9 weeks))
- Matrix Reasoning Test(pre- to post-intervention (0 to 9 weeks))
- State-Trait Anxiety Inventory(pre- to post-intervention (0 to 9 weeks))