EUCTR2015-001699-23-NL进行中（未招募）1 期
Pharmacokinetics and clinical effects of escalating doses of clonidine in ICU patients - Clonidine kinetics 1.1
相关药物
试验速览
- 阶段
- 1 期
- 状态
- 进行中（未招募）
- 入组人数
- 32
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional clinical trial of medicinal product
入排标准
- 性别
- All
入选标准
- •at least 18 years of age
- •at the start of the study. Because of the high incidence of delirium on the ICU in all age categories, all age groups > 18 years will be included.
- •Are the trial subjects under 18? no
- •Number of subjects for this age range:
- •F.1.2 Adults (18-64 years) yes
- •F.1.2.1 Number of subjects for this age range 16
- •F.1.3 Elderly (>=65 years) yes
- •F.1.3.1 Number of subjects for this age range 16
排除标准
- •Severe neurotrauma,
- •Severe dementia (living in a nursing home)
- •Inability to speak Dutch or English, which is one of the causes of not being able to use the CAM-ICU.
- •The use of clonidine during the 96 hours before the start of the study.
- •Bradycardia (<50/min)
- •Severe hypotension (MAP < 65 after volume resuscitation and vasopressors)
- •Pregnancy and lactation (pregnancy test are routinely performed in premenopausal women on the ICU).
- •Known clonidine intolerance
- •Liver cirrhosis (Child Pugh class C)
- •Recent and acute myocardial infarction
- •Severe heart failure (LVEF < 30%)
- •Second or third degree AV-block without a permanent pacemaker
- •Expected transfer to another hospital.
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