The effect of L-citrulline supplementation on nutrirtional, metabolic, oxidative and inflammatory status and serum levels of L-citrulline and NOx in type 2 diabetes patients: A randomized controlled clinical trial

Tabriz University of Medical Sciences0 个研究点目标入组 46 人开始时间: 待定最近更新: 2019年12月17日

试验速览

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•Suffering from type 2 diabetes that have passed at least 6 months since diagnosis and having HbA1c less than 9.
•Men and non-menopausal women
•Age 25 to 55 years
•BMI 25 to 35 kg/m2
•People who control their diabetes just by using metformin and sulfonylurea
•Willingness to participate in the study

•Pregnancy, lactation or menopause in women
•Smoking or alcohol use
•A history of following a particular diet (at the time of the study or 3 months before the study)
•Change in the type or dosage of medications consumed, the type and amount of physical activity, changes in the diet at the start and during the study
•Using synthetic or herbal drugs for weight loss
•Use of any supplement (L-arginine, glutamine, multivitamin, antioxidant supplement, etc.) during the three months before or during the study.
•Taking insulin
•Suffering from cardiovascular disease, liver, intestinal, thyroid and parathyroid dysfunction, polycystic ovary syndrome, cancers and malignant diseases such as sprue and Crohn's disease
•Having symptoms of infectious or inflammatory disease or recent surgery
•The use of hypotensive and lipid-lowering drugs
•Use of corticosteroids and non-steroidal anti-inflammatory drugs for 3 months before the study.

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