Aging, Lifestyle and Inflammation in Veterans Exercising

University of Maryland, Baltimore1 个研究点分布在 1 个国家目标入组 100 人2005年7月1日

适应症Inflammation Aging Metabolism Exercise

干预措施Weight loss and aerobic exercise training

概览

阶段: 不适用
干预措施: Weight loss and aerobic exercise training
疾病 / 适应症: Inflammation
发起方: University of Maryland, Baltimore
入组人数: 100
试验地点: 1
主要终点: Regional Adipokine Release
状态: 已完成
最后更新: 2个月前

概览研究者入排标准研究组 & 干预措施结局指标研究点相似试验

概览

简要总结

Over half of adults in this country are overweight. This increases risk for heart and blood pressure problems, cancer, stroke and arthritis. While it is difficult to lose large amounts of weight and keep it off, even small amounts of weight loss can improve health. Furthermore, fat is increasingly recognized as a source of substances that increase inflammation. It may be that some of the adverse consequences of being overweight are due to increased inflammation. We are asking you to volunteer for a research study in which you may lose a moderate amount of weight and increase your activity. It is important that you read and understand the information on this form.

The purposes of these studies are to determine the influence(s) of age and body composition on the production of inflammatory chemicals by fat (adipose tissue), the mechanisms controlling this, and if a weight loss and aerobic exercise intervention results in a decrease in inflammation.

详细描述

Adipose tissue is increasingly recognized as more than an inert depot serving not only to accept and store excess energy in the form of triglycerides, but also to secrete hormones and adipokines that have substantial effects on lipid and glucose metabolism. Furthermore, there are depot differences in metabolic function, as well as adipokine content. However, the physiology both underlying and consequential to these observations remains unknown. This research is therefore designed to examine: 1\) the effects of aging and obesity on regional adipokine secretion and expression, 2) whether elevated adipokine levels in older obese people are due to increased macrophage infiltration into subcutaneous adipose tissue and/or related to total, subcutaneous or visceral abdominal fat (SAT or VAT) distribution, and 3) the relationship of adipokines to insulin resistance and the constituents of the metabolic syndrome. Specifically, we aim to determine: 1. if the expression and secretion of a) the inflammatory markers SAA, IL-6, TNF-a, MCP-1 is greater, and b) the anti-inflammatory hormone adiponectin is lower in SC abdominal and gluteal adipose tissue from older, compared to middle-aged and younger obese subjects across a narrow range of obesity and waist circumference; 2. if these age-associated changes in adipokine production are a)due to the degree of macrophage infiltration of regional adipose tissue, and/or differences in a greater degree of visceral and/or differences in ABD fat distribution (SAT, VAT), and b) related to glucose and lipid metabolic profiles of the subjects; and 3. the effects of a WL+AEX intervention on regional adipokine expression and secretion, circulating levels of CRP and the above adipokines, and glucose and lipid metabolism in a subset of obese sedentary individuals with greater than two components of the metabolic syndrome.

注册库

clinicaltrials.gov

开始日期

2005年7月1日

结束日期

2018年9月13日

最后更新

2个月前

研究类型

Interventional

研究设计

Single Group

性别

All

研究者

发起方

University of Maryland, Baltimore

责任方

Principal Investigator

主要研究者

Jacob Blumenthal

GRECC Investigator

University of Maryland, Baltimore

入排标准

入选标准

•BMI 20-40 kg/m2
•Waist 80-120cm (men), 70-110cm (women)
•Stable Medical Regimen \> or = 30 days
•All women over the age of 50 must be postmenopausal for at least 1 year, have serum FSH \>30 mIU/ml, and agree to remain off hormone replacement therapy for the duration of the study