Psoriasis and Non Alcoholic Steatohepatitis: Is There a Shared Inflammatory Network ?
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 59
- 主要终点
- Main
研究概览
简要总结
The study is to assess frequency of NASH in Psoriatic patient and to measure the level of proinflammatory cytokines including TNFα, interleukin (IL)-6 and IL-17 and anti-inflammatory cytokines including IL10, IL35 by ELISA.
详细描述
• Psoriasis is a chronic proliferative and inflammatory condition of the skin. It is characterized by erythematous plaques covered with silvery scales, particularly over the extensor surfaces, scalp, and lumbosacral region.
The disorder can also affect the joints and eyes. Psoriasis has no cure and the disease waxes and wanes with flareups. There are several subtypes of psoriasis but the plaque type is the most common and presents on the trunk, extremities, and scalp.
Psoriasis has a prevalence ranging from 0.2% to 4.8%.
In parallel, nonalcoholic fatty liver disease (NAFLD) is the most frequent liver disease worldwide, affecting an estimated 30% of the adult population in developed countries.
NAFLD and the metabolic syndrome are mutually and bi-directionally associated, as these two pathologic condition share insulin resistance as a common pathophysiological mechanism.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Any naive psoriatic patient above 18 years old.
排除标准
- •Any psoriatic patient who received treatment for psoriasis.
- •Diabetic patients.
- •Patients under 18 years old.
- •Patient's refusal.
结局指标
主要结局
Main
时间窗: Baseline
To find out if there is a shared inflammatory network between psoriasis and Non Alcoholic Steatohepatitis or not.
次要结局
- subsidiary(Baseline)
研究者
Mohamed Adel Mohamed Hussein
Resident doctor
Assiut University