Bioavailability of Carotenoids and Flavonoids From Fresh Oranges and Orange Juice.
试验速览
- 阶段
- 不适用
- 入组人数
- 12
- 试验地点
- 2
- 主要终点
- Mean AUC (nmol/L*9.5 h) of beta-cryptoxanthin concentration in blood plasma chylomicrons after ingestion of fresh oranges and orange juice, respectively.
研究概览
简要总结
The study was designed as a randomized 2-way cross-over study to assess the bioavailability of carotenoids and flavonoids from sweet oranges and orange juice. Volunteers followed a wash-out period for 2 weeks prior to eating either 400 g of fresh oranges or 719 g of orange juice. The amount of test food was adjusted to deliver an equal amount of β-cryptoxanthin (740 µg). After a consecutive wash-out period of 2 weeks, the procedure was repeated and the volunteers ingested the complementary test food. Blood samples were collected at 8 time points up to 9.5 h after test meal consumption. Additionally, 24 h-urine was collected to evaluate flavonoid recovery.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 23 Years 至 30 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Healthy adult men and women
- •BMI: 17-60
- •Age: 18-65
排除标准
- •Women who are lactating or pregnant or plan to be pregnant
- •Individuals using tobacco products
- •Individuals with metabolic or malabsorption disorders
- •Individuals with a history of cancer
- •Individuals with a history of liver insufficiency
- •Individuals with a history of chronic and lipid metabolism-related diseases
- •Individuals with an allergy to oranges
- •Obese individuals (BMI > 30)
结局指标
主要结局
Mean AUC (nmol/L*9.5 h) of beta-cryptoxanthin concentration in blood plasma chylomicrons after ingestion of fresh oranges and orange juice, respectively.
时间窗: 0 - 9.5 h after each intervention
次要结局
- Mean hesperetin and naringenin concentration (µmol/L) in 24 h-urine after ingestion of fresh oranges and orange juice, respectively.(0 - 24 h after each intervention)
- Mean AUC of hesperidin- and narirutin-metabolite concentration in blood plasma after ingestion of fresh oranges and orange juice, respectively.(0 - 9.5 h after each intervention)