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临床试验/NCT06979258
NCT06979258招募中不适用

Heat Stress: Exposure Among Low-Income Residents in Bangladesh and Evaluation of Indoor Interventions

University of California, Berkeley1 个研究点 分布在 1 个国家目标入组 1,539 人开始时间: 2025年5月12日最近更新:
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
1,539
试验地点
1
主要终点
Heart rate

研究概览

简要总结

The goal of this clinical trial is to learn if infrastructure and equipment installed to cool homes reduce adverse health outcomes. The main questions it aims to answer are:

What is the impact of the intervention on indoor heat stress? What is the impact of the intervention on personal exposure to heat stress? What is the impact of the intervention on health outcomes, including heart rate, and heart rate variability, and sleep quality?

Participants will have cooling infrastructure and/or equipment installed in their home; have heat stress sensors installed inside and outside their home and wear personal heat stress monitors; allow some biological functions such as heat rate, heat rate variability, and sleep quality.

详细描述

During the last two decades, nearly half a million people died each year from heat-related causes; climate change is expected to exacerbate the burden of adverse health outcomes. Heat stress has been associated with an increase in all-cause mortality, cardiovascular disease and mortality, chronic respiratory disease, lower respiratory infection, chronic kidney disease, diabetes, adverse pregnancy outcomes, and poor mental health. The investigators will to determine personal heat stress of low-income individuals who do not have access to air conditioning, evaluate the effectiveness, acceptability, feasibility, and scalability of building-level cooling strategies to reduce indoor heat stress among vulnerable individuals, and evaluate the impact of these interventions on heart rate. A disproportionate burden of heat-related death and disease is borne by low-income communities because they do not have access to cooling and suffer from comorbidities that exacerbate the adverse impacts of heat stress. South Asia faces the greatest current and predicted loss in disability-adjusted life years due to heat stress, and heat stress is particularly strong in informal settlements. As such, the investigators plan to conduct this study in informal settlements in Dhaka, Bangladesh. The overall hypothesis is that individuals who live in homes with corrugated iron roofs and walls are at elevated risk of heat stress and that it is possible to modify homes to prevent increases in heart rate associated with heat stress, ultimately reducing cardiovascular morbidity and mortality. The investigators will evaluate the impact of cooling infrastructure and/or equipment interventions on residents' heart rate (primary outcome), heart rate variability, sleep quality, self-reported thermal comfort, mental health, wellness, fatigue, and indoor thermal conditions (secondary outcomes).

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Single Group
主要目的
Prevention
盲法
Single (Outcomes Assessor)

入排标准

性别
All
接受健康志愿者

入选标准

  • for the house:
  • House is located in an informal settlement in an urban area in Bangladesh
  • The house has a corrugated iron roof and corrugated iron walls
  • The household plans to remain in the house from Feb-Nov

排除标准

  • for the house
  • There is an inhabited structure about the house
  • The landlord does not allow the proposed intervention
  • Inclusion Criteria for the participant:
  • Lives in an eligible household
  • Exclusion Criteria for the participant
  • Has access to air conditioning in their home or place of work
  • Reports they are pregnant
  • Has hypertension, as measured by study staff
  • Has diabetes, as measured by study staff
  • Self-reports cardiovascular disease / chronic cardiac condition
  • Self-reports respiratory disease / chronic respiratory condition

研究组 & 干预措施

Indoor cooling intervention

Experimental

Households in this arm will receive infrastructure and/or equipment intended to cool the house in the hot season.

干预措施: Cooling intervention (Other)

Control

No Intervention

Households in this arm will not receive any intervention

结局指标

主要结局

Heart rate

时间窗: 0, 2, and 4 weeks

resting heart rate (beats per minute, bpm), where lower heart rate is better

次要结局

  • Heart rate variability(0, 2, and 4 weeks)
  • Sleep quality(0, 2, and 4 weeks)
  • Irritability(0, 2, and 4 weeks)
  • Environmental Symptoms(0, 2, and 4 weeks)
  • Depression(0, 2, and 4 weeks)
  • Anxiety(0, 2, and 4 weeks)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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