A multicenter study on early prediction of antipsychotic response in patients with schizophrenia - A multicenter study on early prediction of antipsychotic response in patients with schizophrenia

Results At 4 weeks, 81% of risperidone ERs (n=47) achieved >=50% response, whereas only 9% of staying risperidone ENRs (n=11) achieved >=50% response (P<0.0001). In contrast, 58% of olanzapine ERs (n=33) achieved >=50% response, whereas 25% of staying olanzapine ENRs (n=8) achieved >=50% response (P=0.12). Irrespective of the initial antipsychotics, there were no significant differences in outcomes at 4 weeks between staying ENRs and switching ENRs. Conclusion In newly admitted acute schizophrenic patients, non-response to risperidone using CGI-I at 2 weeks can predict subsequent clinical outcomes. However, non-response to olanzapine cannot necessarily be predicted at 2weeks.