The Effects of Acute Bouts of Moderate and Intense Exercise on Alcohol and Cocaine Craving - an fNIRS Study
试验速览
- 阶段
- 不适用
- 入组人数
- 60
- 试验地点
- 2
- 主要终点
- Stroop test accuracy
研究概览
简要总结
The study is a crossover randomised controlled trial. Alcohol or cocaine dependent participants will be recruited from inpatient and outpatient psychiatric treatment centres, on the approval of their treating physician. A healthy control group will be recruited using online advertising. All participants will undergo each of three conditions in a randomised order; 1) 20 minutes of cycle ergometry at 50-60% of maximum heart rate; 2) 20 minutes of exercise at 70-80% of maximum heart rate; 3) 20 minutes of quiet reading. Immediately before and after each condition, participants will be asked to complete a computerised Stroop test, watch a film containing substance-related images, and self-report craving levels. During the Stroop test and film viewing, participants' neural activity will be measured via functional near-infrared spectroscopy
详细描述
The aim of this study is to examine whether, following acute exercise bouts at moderate and high intensities, reduced craving and increased inhibitory control can be observed in alcohol or cocaine dependent individuals. As the focus of this study is the potential of exercise to be integrated into treatment, individuals in treatment for their dependence, who have been abstinent for a short period, will be recruited.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 75 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For alcohol or cocaine dependent participants:
- •meeting three or more of the DSM-IV criteria for substance dependence (as determined by treating physician);
- •minimum of 20 days and maximum of 40 days abstinence from substance of dependence;
- •able to understand and complete the informed consent;
- •able to travel to study site independently, as confirmed by the treating psychiatrist;
- •assessed for physical and mental fitness by treating physician and cleared to take part in the study;
- •fewer than 3 hours of physical exercise or sport per week;
- •For healthy controls:
- •fewer than 3 hours of physical exercise or sport per week;
- •no history of problematic alcohol or illicit drug consumption.
排除标准
- •Pregnancy
- •Questionable findings during resting ECG screen
结局指标
主要结局
Stroop test accuracy
时间窗: Change from Baseline after 20 minute acute condition
Accuracy on Stroop test
Stroop test reaction time
时间窗: Change from Baseline after 20 minute acute condition
Reaction time on Stroop test
Self-reported craving
时间窗: Change from Baseline after 20 minute acute condition
Sum score on Alcohol Craving Questionnaire Short Form (scale range 12 to 84, higher scores representing greater craving) or Cocaine Craving Questionnaire - Brief (scale range 10 to 70, higher scores representing greater craving)
Cerebral oxygenation in prefrontal cortex
时间窗: Change from Baseline after 20 minute acute condition
Functional near infrared spectroscopic imaging of hemodynamic activity in prefrontal cortex
次要结局
未报告次要终点
研究者
Flora Colledge
Postdoctoral researcher
University of Basel