NCT06667414已完成不适用
Frequency of Selected Single Nucleotide Polymorphisms in Phase With the Mutant and Wild-Type HTT Alleles in Huntington Disease Gene Expansion Carriers
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 574
- 试验地点
- 87
- 主要终点
- Frequencies of Selected Single Nucleotide Polymorphism (SNP) Alleles in Phase With the mHTT and wtHTT Alleles
研究概览
简要总结
For participation in this epidemiological study, a single-day visit at the study site is required. Participants will be recruited from Huntington Disease clinics, and they will be asked to answer questions regarding their demographics, including sex, age, race and ethnicity, and their medical and medication history. At the end of the visit, a blood sample will be drawn to allow testing with a sequencing assay that is specifically designed for phasing single nucleotide polymorphisms (SNPs) on the wild-type Huntington (wtHTT) and mutant Huntington (mHTT) alleles.
研究设计
- 研究类型
- Observational
- 观察模型
- Other
- 时间视角
- Other
入排标准
- 年龄范围
- 25 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Have signed the Informed Consent Form (ICF)
- •Aged 25 to 60 years, inclusive, at the time of signing the ICF
- •Confirmation of Huntington Disease (HD) gene expansion mutation carrier status
- •Confirmation of Total Functional Capacity (TFC) ≥9 and Total Motor Score (TMS) >6 within 12 months prior to signing the ICF
- •Ability to tolerate blood draws
排除标准
- 未提供
研究组 & 干预措施
Participants Who Are Huntington Disease Gene Expansion Carriers
结局指标
主要结局
Frequencies of Selected Single Nucleotide Polymorphism (SNP) Alleles in Phase With the mHTT and wtHTT Alleles
时间窗: Day 1
次要结局
- Number of Participants With Selected SNPs According to Their Medical History(Day 1)
- Number of Participants With Selected SNPs According to Their Medication History(Day 1)
- Number of Participants With Selected SNPs According to Their Demographic Characteristics (Age, Sex, Ethnicity, and Race)(Day 1)
研究者
研究点 (87)
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