Prevention of Dermatitis in Epoxy Exposed Lamination Workers Producing Wind Turbine Blades: An Intervention Study Using Fluorescence Visualization
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 250
- 试验地点
- 1
- 主要终点
- Change in prevalence of dermatitis
研究概览
简要总结
The risk of sensitization and contact dermatitis among workers exposed to epoxy resin systems (ERS) is high despite extensive preventive efforts, probably because skin exposure is often left unrecognized.
The main objective of this project is to prevent epoxy-related dermatitis and sensitization, caused by working with ERS, by fluorescence visualization of exposure. In cooperation with global manufacturers of wind turbines, 250 lamination workers will be allocated to either an intervention or a control Group. The risk of dermatitis and sensitization will be compared. Skin exposure will be made visible by a fluorescent tracer added to the ERS. UVA-light will illuminate the skin of head, neck, arms and hands and the fluorescent areas will be recorded and quantified by a computer vision system. The intervention group will be shown the fluorescent areas on their skin, while the control group will not have this information. The intervention takes place daily for a period of 1 month, 4 times during the 2 year follow up period.
All participants are patch tested, screened for dermatitis and atopy at start and end of follow up or at end of employment. The investigators also assess potential determinants for ERS exposure including working tasks and procedures. Information on dermatitis diagnoses from hospital contacts, medical prescriptions and education will be obtained from registers.
详细描述
Objectives The overarching objective is to reduce the risk of dermatitis and sensitization when working with epoxy resin systems.
Specific aims are:
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To identify work procedures at increased risk of dermal exposure to epoxy resins
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To examine if fluorescence visualization of dermal exposure to epoxy resins reduces the risk of:
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subsequent dermal exposure to epoxy resins
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dermatitis
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sensitization to epoxy resins
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To examine the risk of dermatitis following sensitization to ERS components
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To examine the course of sensitization to ERS components.
Materials and methods Study population The study population is 250 employees of two factories producing rotor blades for wind turbines. The participants all have daily manual work with ERS. Participants will be recruited through the Health Safety and Environment (HSE) organizations by oral and written information. Current employees will be followed for 2 years. Employees employed during the study will continuously be recruited and followed until end of follow up, 2 years after study start.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •18 years of age or more
- •Understand Danish or English
排除标准
- •Pregnant women
- •Severe dermatitis
- •Current treatment with prednisolone
研究组 & 干预措施
Interventiongroup
The intervention group will be shown the fluorescent areas on their skin (fluorescence visualization feedback)
干预措施: Fluorescence visualization (feedback) (Device)
Control group
The control group will not be shown the fluorescent areas on their skin (no feedback)
结局指标
主要结局
Change in prevalence of dermatitis
时间窗: At start and after 2 years
Diagnosed by clinical examinations
Change in sensitization
时间窗: At start and after 2 years
Assesed by patch test
次要结局
- Change in fluorescence levels(1 month x 4, over 2 years)
- Change in number of fluorescence recordings(1 months x 4, over 2 years)
