NCT00610597已完成不适用
Study of T Cell Phenotype Activation Pathway in Human Alcoholic Liver Disease
Erasme University Hospital1 个研究点 分布在 1 个国家目标入组 49 人开始时间: 2005年1月最近更新:
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 49
- 试验地点
- 1
研究概览
简要总结
Alcoholic liver disease is characterized by circulating T cell activation and liver T cell infiltration but their phenotype is poorly studied. The aim of the study is to test the hypothesis that the (CD4+ T cell secreting Interleukin-17) Th17 pathway is involved in alcoholic liver disease.
详细描述
Consecutive patients undergoing transjugular liver biopsies for alcoholic liver disease or hepatitis C virus infection will be included in the study to measure plasma cytokines levels, peripheral blood mononuclear cells cytokine release and liver T cell infiltrates.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Alcohol excess intake and suspected liver disease
- •Alcohol excess intake and clinical liver cirrhosis
- •chronic hepatitis C virus infection and suspected liver disease
- •chronic hepatitis C virus infection and clinical liver cirrhosis
排除标准
- •bacterial or fungal infection
- •immunosuppressive treatment
- •other causes of liver disease
研究者
研究点 (1)
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