Exercise Capacity, Physical Activity Level and Quality of Life in Newly Diagnosed Hematologic Malignant Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Disease-specific quality of life
研究概览
简要总结
Hematologic malignancies are neoplasms that affect the blood, bone marrow, and lymph nodes. Hematological malignancies are the most common forms of leukemia, lymphoma, and myeloma, with numerous subtypes. The general symptoms of leukemia are fatigue, increased susceptibility to infection, bleeding, and the formation of bruises easily. Typical lymphoma symptoms are night sweats and involuntary weight loss, recurrent fever, fatigue, and itching. Myeloma patients often have bone pain, fatigue, anemia, hypercalcemia or infection symptoms.
Adverse effects of hematologic malignancies and treatments cause abnormality in physical function and quality of life. Treatments such as chemotherapy, radiotherapy and hematopoietic stem cell transplantation, which may have side effects on the body systems are used in early or late period. The most common side effect due to chemotherapy is fatigue. Vomiting, weight loss, anemia, depression, decreased aerobic capacity, loss of muscle strength, decreased physical functioning and deterioration in the quality of life are indirect side effects seen in patients.
In the literature, side effects of hematological malignancies have been investigated after treatment in patients. However, no study investigated exercise capacity, quality of life, physical activity level and pulmonary functions on newly diagnosed hematologic malignant patients. Therefore, the investigators aimed to compare aforementioned outcomes in newly diagnosed hematologic malignant patients and healthy controls.
详细描述
According to sample size calculation 30 newly diagnosed hematologic malignant patients and 30 healthy individuals will be included. Before treatment submaximal exercise capacity, physical activity, quality of life, pulmonary functions, respiratory and peripheral muscle strength, respiratory muscle endurance, dyspnea and fatigue perception, anxiety and depression will be evaluated. Primary outcome measurements are exercise capacity, physical activity, quality of life, secondary outcomes are respiratory and peripheral muscle strength, respiratory muscle endurance, pulmonary functions, dyspnea and fatigue perception, anxiety and depression.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Newly diagnosed hematological malignant patients
- •18-65 years of age
- •under standard medications.
排除标准
- •having cognitive disorder,
- •orthopedic or neurological disease with a potential to affect functional capacity,
- •comorbidities such as asthma, chronic obstructive pulmonary disease (COPD), acute infections or pneumonia,
- •problems which may prevent evaluating such as visual problems and mucositis
- •having metastasis to any region (bone etc.)
- •having acute hemorrhage in the intracranial and / or lung and other areas
- •having any contraindication to exercise training
结局指标
主要结局
Disease-specific quality of life
时间窗: second day
The Functional Assessment of Cancer Therapy-Leukemia (FACT-Leu)
Functional exercise capacity
时间窗: first day
Evaluated using 6-minute walking test
FACT
时间窗: second day
The Functional Assessment of Cancer Therapy-Anemia (FACT-An)
Physical activity
时间窗: first day
Evaluated using a metabolic holter
General quality of life
时间窗: second day
Evaluated using QOL using European Organization for Research and Treatment of Cancer QOL Questionnaire (EORTCQOL)
次要结局
- Activity dyspnea(first day)
- Depression(second day)
- Fatigue(second day)
- Dyspnea(first day)
- Pulmonary functions(first day)
- Hospital depression(second day)
- Anxiety(second day)
- Respiratory muscle strength(second day)
- Muscle strength(second day)
- Respiratory muscle endurance(second day)
研究者
Meral Boşnak Güçlü
Associate professor
Gazi University