Early-onset Obesity and Cognitive Impairment in Children With Pseudohypoparathyroidism
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 39
- 试验地点
- 1
- 主要终点
- Intelligence Quotient
研究概览
简要总结
Pseudohypoparathyroidism type 1a (PHP1a) is a rare disease that causes childhood obesity and learning difficulties. This study will investigate eating behaviors and perform cognitive testing on children with PHP1a. The investigators will compare their results to those of healthy siblings and other obese children.
详细描述
Pseudohypoparathyroidism type 1a (PHP1a) is a genetic disorder that causes early-onset, syndromic obesity and cognitive impairment. This study aims to evaluate eating behaviors, cognition and executive function in children with PHP1a, compared with healthy siblings and matched obese controls.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 6 Years 至 18 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of PHP1a, sibling of a patient with PHP1a or matched obese control
- •Exclusion Criteria (PHP1a):
- •Treatment with appetite-altering drug or initiation of a new weight loss program in the past 3 months
- •Type 2 diabetes
- •Exclusion Criteria (Controls):
- •Obesity due to a genetic syndrome, growth hormone deficiency, untreated hypothyroidism, Cushing syndrome or exogenous glucocorticoid administration
- •Weight loss greater than 10% over the previous 6 months
- •Autism or other significant learning disorder
- •Type 2 diabetes
- •Other significant medical condition
排除标准
- 未提供
结局指标
主要结局
Intelligence Quotient
时间窗: one day
Intelligence quotient as measured by Kaufman Brief Intelligence Test, 2nd Edition. This scale yields standard scores where the mean is 100 and one standard deviation is 15. Higher scores indicate better function.
次要结局
未报告次要终点
研究者
Ashley Shoemaker
Assistant Professor of Pediatrics, Pediatric Endocrinology and Diabetes
Vanderbilt University Medical Center