NCT06681818招募中不适用
Postoperative Heme Oxygenase Induction and Carbon Monoxide Production as a Novel Method to Assess Hepatic Regeneration and Predict Hepatic Related Morbidity After Partial Hepatectomy
适应症
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 125
- 试验地点
- 2
- 主要终点
- correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
研究概览
简要总结
the investigators will pursue two specific aims: (1) to monitor the extent of heme oxygenase induction (by measuring endogenous CO production) in relationship to the extent of hepatic resection (2) to assess the production of CO in patients following liver resection and correlate these findings to the rate of liver regeneration and liver function.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patient plans to have partial liver resection for primary liver pathology or metastatic disease
- •Patient is able to comprehend and willing to sign the written consent form
排除标准
- •Patients < 18 years
- •Patients identified as members of a vulnerable population, except women of child bearing potential with negative pregnancy test
结局指标
主要结局
correlation of carbon monoxide levels in exhaled breath with quantity and quality of liver regeneration
时间窗: measurements will be taken pre, then 4 hours and 24 hours post resection
patients will be asked to donate exhaled breath into a smokerlyzer device
次要结局
- level of carbon monoxide in exhaled air of patients(measurements will be taken pre, then 4 hours and 24 hours post resection)
- quantity of liver regeneration, liver volume (ml)(one and three months after resection)
- quality of hepatic regeneration, normalized liver function(one and three months post resection)
研究者
研究点 (2)
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