Antibiotic Prophylaxis in Bariatric Surgery With Continuous Infusion of Cefazolin: Determination of Concentration in Adipose Tissue
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- dosage of Cefazolin in adipose tissue during bariatric surgery
研究概览
简要总结
Eighteen patients were given a dose of 2g Cefazolin in anesthetic induction, supplemented with 1g delivered through continuous infusion during surgery. Adipose samples, obtained at the beginning and end of surgery, were analyzed using high performance liquid chromatography.
Some published studies suggest that the dose of 2g does not supply the minimum inhibitory concentration for principal causal agents of surgical site infection.
To determine the concentration of Cefazolin in adipose tissue of patients undergoing bariatric surgery and to evaluate the relationship between concentrations obtained and body mass index (BMI).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- Single (Investigator)
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •body mass index greater than 35 and less than 50kg/m2
排除标准
- •Hypotension during surgery with use of vasoactive drugs
- •renal disfunction (creatinine >1.5 mg/dL)
研究组 & 干预措施
Cefazolin
Cefazolin used in antimicrobial prophylaxis
Cefazolin administered a first dose of 2g in anesthetic induction, followed by continuous dosage of 1g diluted in 250mL of saline solution for two hours.
Two samples of subcutaneous tissue were collected for analysis: the first soon after the incision, and a second before skin synthesis.
The samples were processed by High Pressure Liquid Chromatography (HPLC).
干预措施: Cefazolin used in antimicrobial prophylaxis (Drug)
结局指标
主要结局
dosage of Cefazolin in adipose tissue during bariatric surgery
时间窗: eight months
次要结局
未报告次要终点
研究者
Rafael Anlicoara
Master´s degree
Universidade Federal de Pernambuco