Individualized Lung Recruitment Maneuver Guide by Pulse-oximetry in Anesthetized Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- open-lung condition
研究概览
简要总结
General anesthesia and mechanical ventilation promotes atelectasis and airway closure. The open-lung approach (OLA) strategy restores the functional residual capacity. Pulse oximetry hemoglobin saturation (SpO2) using room air can diagnose shunt induced by lung collapse during general anesthesia and the SpO2 breathing air was useful to detect the lung´s opening and closing pressure during a recruitment maneuver (RM) in morbidly obese anesthetized patients.
Investigators hypothesized that the SpO2 breathing air can personalize the open-lung approach.
详细描述
Increase in airway pressure until the SpO2 reaches 97% (lung´s opening pressure) during the incremental positive end-expiratory (PEEP) limb. Decrease in the PEEP level until the SpO2 decreases bellow 97% (lung´s closing pressure)
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Non-obese patients with ASA physical status I-III undergoing elective abdominal laparoscopic surgery with an expected operating time of less than 2 hours were included.
排除标准
- •age of <18 years,
- •preoperative SpO2 ≤97% while breathing room air, and
- •patients with previous known cardiac or respiratory disease.
结局指标
主要结局
open-lung condition
时间窗: During the experimental protocol (Intraoperative)
The role of the SpO2 to detect lung´s closing and opening pressures was evaluated by the discrete receiver operating characteristic (ROC) analysis. With PtpEE and PaO2/FIO2 as the reference methods, a binary classification of "1" to the open-lung condition defined as positive PtpEE or PaO2/FIO2 \>400 mmHg and "0" presence of lung collapse defined as negative PtpEE or PaO2/FIO2 \<400 mmHg. Also, a value of "1" was assigned when the SpO2 was ≥ 97% and a value of "0" when the value was \< 97%.
次要结局
未报告次要终点
研究者
Carlos Ferrando
MD, PhD
Fundación para la Investigación del Hospital Clínico de Valencia