IRCT20180908040972N1招募中3 期
The Effect of Vitamins B6, B9, B12 Supplementation on Liver Enzymes, Inflammatory and Oxidative Stress Markers, Insulin Resistance, Lipid Profile and Serum Homocysteine in Overweight or Obese Patients with Nonalcoholic Fatty Liver Disease
试验速览
- 阶段
- 3 期
- 状态
- 招募中
- 入组人数
- 50
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 25 years 至 65 years（—）
- 性别
- All
入选标准
- •Willingness to participate in study
- •Age range from 25 to 65 years
- •Body mass index (BMI) from 25 to 40 kg /m2
- •Serum alanine aminotransferase (ALT) greater than the upper reference limit and steatosis grade > 1 on ultrasonography
排除标准
- •Alcohol abuse (more than 20 grams per day in women and 30 grams per day in men)
- •Acute and chronic liver diseases (all types of hepatitis? biliary disease? cirrhosis? inherited disorders affecting liver condition such as storage disease of iron, and copper? etc.)
- •Gastrointestinal diseases (gastritis, celiac, steatorrhea, crohn, colitis, gastrointestinal bypass surgery, etc.)
- •Hypertension and cardiovascular diseases
- •Renal disease, lung disease, autoimmune diseases, rheumatoid arthritis, multiple sclerosis, cancer, thyroid disorders, epilepsy, diabetes
- •All types of anemia, thalassaemia, A-beta-lipoproteinemia, hypoalbuminemia
- •Hereditary disorders in homocysteine metabolizing enzymes
- •Hepatotoxic drugs, gastric acid suppression drugs, antiepileptic drug and medications such as corticosteroids, contraceptive pills estrogen, progesterone, androgen, levodopa, cycloserine, phenelzine, isoniazid, penicillamine, sulfasalazine
- •Weight loss during the last 6 months
- •Follow special diet (weight loss diet, vegeterian diet, etc.)
- •History of weight loss surgery in the last year
- •Taking any dietary or herbal supplements during the last 6 months
- •History of allergy or intolerance or unlikely side effects from taking vitamins B6? B9? B12 supplements
- •Pregnancy or lactation
研究者
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