A randomized study to assess and compare the efficacy of cyclosporine versus azathioprine in the treatment of chronic refractory urticaria.

il0 个研究点目标入组 0 人开始时间: 待定最近更新: 2021年11月24日

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•chronic spontaneous urticaria, with disease duration of at least 6 months or above, which is not controlled with four fold increased dosage of antihistamines (as per EAACI guidelines), given for at least three consecutive months and requiring repeated courses of oral corticosteroids. There is no strict number of oral corticosteroids intake courses before the patient can be labeled as chronic refractory urticaria.

•1. Patients giving history of fainting, bronchospasm during previous attacks of urticaria that is suggestive of anaphylaxis.
•2. Urticaria < 6 weeks.
•3. Age <18 years.
•4. Physical and pressure urticaria.
•5. Urticarial vasculitits.
•6. Pregnant and lactating patients.
•7. Cataract, hepatic or renal diseases, severe infections,poorly controlled hypertension
•8. Concomitant intake of drugs like nephrotoxic drugs (gentamycin, vancomycin, amphotericin-B, indomethacin, diclofenac, H2 antihistamines like ranitidine, cimetidine, phenobarbitone, rifampicin, allupurinol, febuxostat).
•9. History suggestive of allergy to azathioprine , cyclosporine.
•10. Absolute contraindications69 of azathioprine are severe infections, severly impaired hepatic or bone marrow function, pancreatitis, live vaccines, pregnancy and lactation.
•11. Patients with chronic kidney disease, uncontrolled hypertension, renal insufficiency,
•uncontrolled infections, cutaneous T-cell lymphoma, including mycosis fungoides, should
•not be given Cyclosporine70.
•12. Patients who are planning pregnancy.

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