ow-dose ketamine as an adjunct to morphine for acute pain in the ED: a randomized, double-blinded, superiority trial

Aarhus University Hospital, Department of Anesthesiology0 个研究点目标入组 160 人开始时间: 2021年10月11日最近更新: 2023年10月3日

试验速览

暂无简介。

•1) Emergency Department admission
•2) Age = 18 years
•3) NRS = 5
•4) Stable vital signs defined as systolic blood pressure = 90 mmHg, heart rate between 50 and 150 per minute, respiratory rate between 8 and 30 per minute, oxygen saturation greater than or equal to 92%.
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range 150
•F.1.3 Elderly (>=65 years) yes
•F.1.3.1 Number of subjects for this age range 10

•1) Initial management by trauma-team
•2) Systolic blood pressure = 180mmHg, severe untreated arrhythmia, unstable angina, recent myocardial infarction (< 30 days), severe heart-failure (Ejection fraction < 40 %)
•3) Symptoms of untreated hyperthyroidism
•4) Cirrhosis with ascites
•5) Known/suspected pregnancy or breastfeeding
•6) Patients for whom consent is not obtainable or psychiatric forced treatment.
•7) Previously enrolled in the trial
•8) Psychiatric illness prior to admission defined as prior psychosis/schizophrenia
•9) Untreated diagnosed glaucoma
•10) Known hypersensitivity to ketamine or to any excipient or prior use of ketamine with a negative experience (i.e. hallucinations)
•11) Patient clearly influenced by drugs or alcohol

发起方

Aarhus University Hospital, Department of Anesthesiology