NCT01792427已完成不适用
Mortality in Non-cystic Fibrosis Bronchiectasis: a Long-term Cohort Analysis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 253
- 试验地点
- 1
- 主要终点
- overall survival
研究概览
简要总结
In this study we analyzed the overall survival for all newly diagnosed patients with non-cystic fibrosis bronchiectasis from June 2006 onwards. The investigators wanted to confirm the known risk factors such as age, gender, smoking history and Pseudomonas aeruginosa and evaluate the impact on survival of etiology, number of different bacteriological species in retrospective and prospective sputa, azithromycin use and presence/development of pulmonary hypertension.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with clinically significant and radiologically proven bronchiectasis
- •Chest CT scan confirming the presence of bronchiectatic lesions and had symptoms of chronic productive cough
- •Bronchiectasis was deemed to be present if there was one or more of the following criteria: a bronchoarterial ratio greater than 1, lack of tapering of the bronchi and visualization of bronchi within 1 cm of costal or paravertebral pleura or abutting the mediastinal pleura
排除标准
- •diagnosis of cystic fibrosis
- •underlying tumoral problem causing the bronchiectatic lesions (postradiotherapy, secondary immunodeficiency due to chemotherapy or postinfectious due to tumoral obstruction)
- •patients with asymptomatic traction bronchiectasis caused by interstitial lung disease
结局指标
主要结局
overall survival
时间窗: 6 years 4 months
次要结局
- risk factor identification for NCFB(6 years 4 months)
研究者
Dr. Lieven Dupont
prof. dr.
Universitaire Ziekenhuizen KU Leuven
研究点 (1)
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