Measurement of the Endothelial Function in Patients With a Abdominal Aortic Aneurism.
试验速览
- 阶段
- 不适用
- 入组人数
- 50
- 试验地点
- 2
- 主要终点
- Endothelial dysfunction
研究概览
简要总结
The investigators want to measure the degradation of the endothelial glycocalyx before and after clamping the aorta, in patients operated for a abdominal aortic aneurism.
详细描述
50 patients is scheduled for enrollment. Blood samples will be up taken before surgery, 10 min after reperfusion, at the end of surgery and the following morning. In addition the investigators are placing a renal venous catheter where blood samples will be up taken as mentioned above for the analysis of endothelial markers together with markers for kidney damage.
The first 10 patient will act as part of a pilot study, where only measurement of the endothelial and renal failure markers will be performed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •above 18 years
排除标准
- •prior engagement in scientific study within the last 30 days.
结局指标
主要结局
Endothelial dysfunction
时间窗: 24 hours
Measurement of endothelial markers peri- and postoperative: thrombomodulin, E-selectin and syndecan-1
次要结局
- Fluid balance(24 hours)
研究者
Thomas Bech Jorgensen
MD
Rigshospitalet, Denmark