NCT05269641招募中不适用
The Effect of Almond Supplementation on Mild to Moderate Acne
适应症
干预措施
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Total lesion count
研究概览
简要总结
This study will assess the effect of almond supplementation on acne and on gut health.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 15 Years 至 45 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Subjects 15 years of age until 45 years of age.
- •The presence of mild to moderate acne based on investigator global assessment.
- •Individuals who have remained stable on their topical or oral acne regimen for at least 4 weeks, except if the medication is a noted exclusion.
排除标准
- •The presence of severe acne as noted by the investigator global assessment.
- •Those with a nut allergy.
- •Those who are unwilling to discontinue oral probiotic-based supplementation to meet the washout criteria prior to enrolling.
- •Those who are unwilling to discontinue topical antibiotics and topical benzoyl peroxide to meet the washout criteria prior to enrolling.
- •Individuals who are unwilling to discontinue vitamin E containing supplements during the washout and intervention.
- •Individuals who have been on an oral antibiotic for acne within the previous 1 month.
- •Individuals who are pregnant or breastfeeding.
- •Individuals who have changed any of their hormonal based contraception within 3 months prior to joining the study.
- •Oral supplementation that has nuts in it.
- •Use of isotretinoin within the three months prior to joining the study.
- •Current tobacco smoker or a tobacco smoking history of greater than 10 pack-years.
研究组 & 干预措施
Almonds
Experimental
Daily consumption of almonds.
干预措施: Food: whole almonds (Other)
Control Snack
Placebo Comparator
Daily non-nut snack will be consumed.
干预措施: Food: non-nut snack (Other)
结局指标
主要结局
Total lesion count
时间窗: 20 weeks
Number of of inflammatory lesions, and open and closed comedones
次要结局
- Inflammatory lesion count(20 weeks)
- Non-inflammatory lesion count(20 weeks)
- Investigator global assessment (IGA) of acne(20 weeks)
- Quality of Life Survey(20 weeks)
- Sebum excretion(20 weeks)
- Gut microbiome assessment(20 weeks)
- Skin microbiome diversity(20 weeks)
- Inflammatory lesion count(12 weeks)
- Non-inflammatory lesion count(12 weeks)
- Investigator global assessment (IGA) of acne(12 weeks)
- Quality of Life Survey(12 weeks)
- Sebum excretion(12 weeks)
- Gut microbiome assessment(12 weeks)
- Skin microbiome diversity(12 weeks)
研究者
Raja Sivamani, MD MS AP
Principal Investigator
Integrative Skin Science and Research
研究点 (1)
Loading locations...
相似试验
招募中
Unknown
Effect of almond consumption on gut health and glycemic control in adults with prediabetesCTRI/2023/03/050421Almond Board of California
进行中（未招募）
不适用
Almonds to Improve Gut Health and Decrease InflammationInflammationDysbiosisMetabolic SyndromeNCT05790564Oregon State University80
招募中
不适用
To study if eating Almonds daily has any effect on Pimples in humans.CTRI/2023/02/049655Sir Vithaldas Thackersey College of Home Science (Autonomous)26
终止
不适用
Benefits of Almond Consumption in Modulation of Intestinal Microbiome and Novel Disease Risk BiomarkersMicrobiotaNCT03327441University of Manitoba38
招募中
不适用
The Effects of Almond on Facial Skin Collagen and WrinklesElastic SkinCollagen DegenerationWrinklePigmentationNCT06074276Integrative Skin Science and Research60