Longevity Families of the Netherlands
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- 入组人数
- 600
- 试验地点
- 1
- 主要终点
- Identifying the genetic variants of Familial Longevity
研究概览
简要总结
The demographic life expectancy enhancement of the past 150 years imposes an urgent challenge in Western and economically growing societies to stimulate the healthy lifespan that is lagging behind. Families surviving into exceptionally high ages (longevity) in good physical and mental health illustrate that this is physiologically possible. Such families harbor cross generational socio-genetic mechanisms that mediate healthy aging and protection from (multi)morbidity.
The purpose of our research is: to identify gene variants associated with healthy aging and protection from (multi)morbidity; to study the social-, environment- and behavioral factors of familial longevity, their role in (multi-)morbidity and its interaction with the genetic component.
研究设计
- 研究类型
- Observational
- 观察模型
- Family Based
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 75 Years 至 —（Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Siblings of Dutch Caucasian descent age 75+ enriched for familial longevity
- •Individuals of Dutch Caucasian descent age 75+ who are not enriched for familial longevity
排除标准
- 未提供
结局指标
主要结局
Identifying the genetic variants of Familial Longevity
时间窗: through study completion, an average of 2 years
To identify gene variants associated with healthy aging and protection from (multi)morbidity
次要结局
- Studying the environmental factor of Familial Longevity through questionnaires and its interaction with the genetic component(through study completion, an average of 2 years)
研究者
Eline Slagboom
Eline Slagboom, Prof. dr.
Leiden University Medical Center