Fetal Microchimerism and Fetal Stem Cells in Breast Cancer: Analysis of Circulating Fetal Cell Sub-populations in Women With Breast Cancer. CIRCULATING FETAL CELLS AND BREAST CANCER
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- Percentages of fetal cells in each immune cell subpopulation.
研究概览
简要总结
After pregnancy, fetal cells remain in a woman's body for years. These cells may be involved in different physiological situations (e.g. wound healing) and diseases (e.g. cancer).The study will evaluate the level of circulating fetal immune cells in patients with breast cancer vs controls with benign breast tumors, and further characterize these fetal cells. Patients participation will be limited to accepting that an additional blood sample is collected on the day of their preop consultation and blood test.
详细描述
Breast cancer is the most common cancer in the female population. The protective mechanism associated with pregnancy is not fully understood.
During pregnancy fetal cells cross the placental barrier and may remain in the maternal circulation even for up to 30 years after childbirth. This phenomenon is called fetal microchimerism.
The presence of circulating fetal cells would have a protective role against breast cancer. However, their phenotype and role in the anti-tumor response is not explored.
The objective of the study is to identify the sub-population (s) of circulating fetal immune cells that may have an impact on the processes of carcinogenesis in breast cancer, in the context of fetal microchimerism.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •women aged 18-50
- •having had a male child
- •informed and not having objected to participating in the research.
- •having a diagnosis of breast cancer
- •operated on for benign breast tumors
- •cancer free
排除标准
- •autoimmune disease
- •immunomodulatory treatment
- •history of cancer other than breast cancer
- •ongoing hormonal treatment
- •women not affiliated to the social security
- •under AME (state medical aid)
- •under tutorship / curatorship
结局指标
主要结局
Percentages of fetal cells in each immune cell subpopulation.
时间窗: 3 years
Using fluorescence activated cell sorting method.
次要结局
- Activation markers.(3 years)
- Cytotoxicity markers.(3 years)