Inventory of Radiological and Vestibular Function in Cochlear Implant Candidates
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- CT/MR of SCC
研究概览
简要总结
In 2014 radiological lesions at one or more semicircular canals (SCC) were described using CT & MR imaging in subjects presenting advanced hearing and vestibular deterioration caused by the p.P51S mutation in COCH. Similar lesions were also described in other non-genetic advanced hearing and vestibular deterioration as well. With this prospective observational study it is the purpose to inventory imaging results of candidates for cochlear implantation which are routinely performed during the preoperative work up, since these patient present severe hearing impairment at both ears. A considerable part of them might present vestibular deterioration as well. It is the purpose to detect possible presence of these SCC lesions on CT and MR in this population and the prevalence of these lesions compared to DFNA9 patients.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 90 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •must be eligible for cochlear implantation
- •must be 18 years of age or older
排除标准
- •<18 years of age
- •not eligible to undergo vestibular tests, especially videonystagmography
- •contra-indication for MR or CT
结局指标
主要结局
CT/MR of SCC
时间窗: at time of recruitment
lesions to one or more semicircular canals on CT and/or MR of temporal bone
p.P51S
时间窗: at time of recruitment
carriers hip of p.P51S mutation in COCH
次要结局
- vestibular function 1(at time of recruitment)
- vestibular function 2(at time of recruitment)
- audiometry(at time of recruitment)
- vestibular function 3(at time of recruitment)
研究者
Sebastien Janssens de Varebeke
Principal Investigator
Jessa Hospital