Effect of Different Pacing Sites on Cardiac Synchronization and Tricuspid Regurgitation After Leadless Pacemaker Implantation
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- The evaluation of cardiac electrical synchrony
研究概览
简要总结
Comparison of cardiac synchronization and tricuspid regurgitation with or without leadless pacemaker pacing in different site
详细描述
Right ventricular pacing might lead to pacing-induced cardiomyopathy by dyssynchrony and tricuspid regurgitation. Pacing at various sites had different effects on synchrony and tricuspid regurgitation. This study is to observe the effect of leadless pacemaker implantation in different regions on ventricular synchronization and tricuspid regurgitation. Ultrasound and ECG parameter indices are applied.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •patients consent to LP implantation surgery
排除标准
- •Patients with inferior vena cava thrombus, a cancer thrombus, an abnormal inferior vena cava;
- •Patients with femoral vein stenosis and tortuosity failed to accommodate the pacemaker delivery system;
- •Patients with myocardial infarction;
- •Patients who have been implanted with devices that affect the pacemaker delivery system, such as vena cava filters or tricuspid valve mechanical valves;
- •cannot understand or are unwilling to give informed consent.
结局指标
主要结局
The evaluation of cardiac electrical synchrony
时间窗: 1 month
the QRS duration after pacing
The evaluation of cardiac mechanical synchrony
时间窗: 1 month
①Synchronization analysis between left and right ventricles: interventricular mechanical delay (IVMD) in millisecond. ②Left ventricle synchrony analysis: septal-to-posterior wall motion delay (SPWMD) in millisecond，left pre-ejection interval(LPEI) in millisecond.
次要结局
- The pacemaker sensing may affect synchronization(1 month)
- BMI may affect synchronization(1 month)
- Blood pressure may affect synchronization(1 month)
- Age may affect synchronization(1 month)
- The pacemaker lead impedance may affect synchronization(1 month)