Ventilator-associated Pneumonia Ecology Comparison in a French ICU Center NIMES Between First and Second Wave of COVID-19 : a Retrospective Monocentric Descriptive Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 268
- 试验地点
- 1
- 主要终点
- VAP ecological difference between the first and second waves of COVID
研究概览
简要总结
In December 2019, a new pandemic emerged, the COVID-19 disease caused by a SARS-Cov-2 virus. One of the most common symptoms of COVID-19 is mainly respiratory failure and patients requires assistance by mechanical ventilation. Ventilator-associated pneumonia (VAP) is a risk of this assistance. Since the beginning of the pandemic, Standard of care have evolved with new data. The prevalence of these VAPs seems significantly higher in the population of patients with ARDS COVID-19 (40-50%) and their ecology seems to have evolved over time, particularly in terms of bacterial resistance. Investigators want to describe and compare this evolution of bacterial and fungal ecology as well as identify potential risk factors that may be associated with these changes in ecology during different waves.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age > 18 years
- •Positive SARS-Cov-2 polymerase chain reaction (PCR)
- •healthcare associated pneumonia
- •Exclusion Criteria : Patient opposition to participate to the study
排除标准
- 未提供
结局指标
主要结局
VAP ecological difference between the first and second waves of COVID
时间窗: January 2020 to January 2021
Proportion of patients admitted to critical care with documented multidrug-resistant bacteria (MDR) VAP in Covid-19 wave 1 and 2
次要结局
- proportion of fungal co-infections(January 2020 to January 2021)
- Mortality(Day 28)
- proportion of patients treated with corticosteroid therapy(Day 28)
- antiviral treatment(Day 28)
- duration of mechanical ventilation(Day 28)
- probabilistic antibiotic therapy at admission(Day 1)
- number of days of organ failure(Day 28)