Cerebellar Superficial Siderosis in Cerebral Amyloid Angiopathy on 1.5T T2*-Weighted Imaging
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 111
- 试验地点
- 1
- 主要终点
- MRI analyse : presence of cerebellar SS
研究概览
简要总结
Cerebellar superficial siderosis (SS) has been recently reported to be present in about 10% of both hereditary (n=50) and sporadic (n=46) cerebral amyloid angiopathy (CAA) patients on 3T MRI using susceptibility-weighted imaging (SWI) in the majority of patients. In that study, cerebellar SS was associated with a higher number of supratentorial lobar and superficial cerebellar macrobleeds (although cerebellar SS was not directly located adjacent to these cerebellar macrobleeds). It is unclear if cerebellar SS is caused by in situ leakage of cerebellar leptomeningeal vessels or rather represents hemorrhagic diffusion from cerebellar parenchymal micro/macrobleeds or from supratentorial bleeding sources via the tentorium cerebelli (TC).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •CAA patients (according to the modified Boston criteria)
- •with acute symptoms related to acute ICH, acute subarachnoid haemorrhage, or cortical SS
排除标准
- •Patients with recent trauma,
- •Patients with anticoagulation treatment,
- •Patients with pathological blood coagulation tests (activated partial thromboplastin time [aPTT] ratio=patient's aPTT/normal control aPTT] >1.2; or partial thromboplastin time [PTT] <75%) or platelet count (<100 x 109/L)
- •Patients with inflammatory CAA
结局指标
主要结局
MRI analyse : presence of cerebellar SS
时间窗: baseline
presence of cerebellar SS (Yes/No)
MRI analyse : characteristics of cerebellar SS
时间窗: baseline
spatial relationship with cerebellar micro- and macrobleeds
MRI analyse : Characteristics of cortical SS
时间窗: baseline
spatial relationship with TC (adjacent vs. non-adjacent to TC)
MRI analyse : hemosiderin
时间窗: baseline
presence of hemosiderin deposition along the TC.
MRI analyse : Presence of cerebral macrobleeds
时间窗: baseline
Presence of cerebral macrobleeds (Yes/No)
MRI analyse : Location of cerebellar SS
时间窗: baseline
Location of cerebellar SS (vermis, anterior lobe, posterior lobe)
MRI analyse : Presence of cerebellar macrobleeds
时间窗: baseline
Presence of cerebellar macrobleeds (Yes/No)
MRI analyse : Characteristics of cerebral macrobleeds
时间窗: baseline
spatial relationship of cerebral macrobleeds with the TC \[adjacent vs. non-adjacent to TC\]
次要结局
未报告次要终点