Retrospective Investigation of the Effects of Different Uses of Lidocaine in the Prevention of Hemodynamic Response to Laryngoscopy and Endotracheal Intubation
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 94
- 试验地点
- 1
- 主要终点
- Oxygen Saturation
研究概览
简要总结
Direct laryngoscopy and endotracheal intubation procedure stimulate the sympathetic nervous system, causing catecholamine release into the circulation and consequently hemodynamic changes.There are many studies showing that lidocaine is used intravenously to suppress the sympathetic response to laryngoscopy and endotracheal intubation. Nebulized lidocaine is often used to provide upper airway local anesthesia in fiberoptic guided awake intubation.
In this study, the researchers aimed to compare the results of using intravenous lidocaine and nebulized lidocaine to suppress the hemodynamic response caused by laryngoscopy and endotracheal intubation retrospectively.
Researchers' hypothesis; Nebulized lidocaine administration is more effective than intravenous lidocaine administration in suppressing the hemodynamic response due to laryngoscopy and endotracheal intubation in patients under general anesthesia.
详细描述
2% lidocaine drug to suppress the hemodynamic response due to laryngoscopy and endotracheal intubation; patients administered intravenously will be evaluated in one group, and patients administered inhaled through a nebulizer will be evaluated in another group.
Nebulized lidocaine in the researchers' clinic; it is administered by adding 2% lidocaine + physiological saline to a nebulizer and inhaling for 3-5 minutes in the presence of 4-6 liters/minute of oxygen.
Preoperative examination forms and intraoperative follow-up forms of the patients included in the study will be examined by the researchers. The dose of lidocaine applied and the method of administration will be recorded. In addition, the agents used in anesthesia induction (fentanyl, propofol, rocuronium bromide, etc.) and the hemodynamic changes of the patients (heart rate, systolic blood pressure, diastolic blood pressure, mean arterial pressure,oxygen saturation) will be recorded.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients over the age of 18 and under the age of 80 who underwent surgery under general anesthesia
排除标准
- •Patients under the age of 18 and over the age of 80
- •Patients who are not operated under general anesthesia
研究组 & 干预措施
Intravenous lidocaine
Patients who received lidocaine intravenously before induction of anesthesia will be considered in this group.
干预措施: Iv Lidocaine (Drug)
Nebulized lidocaine
Patients who received lidocaine by inhalation with a nebulizer before induction of anesthesia will be considered in this group.
干预措施: Nebulized Lidocaine (Drug)
结局指标
主要结局
Oxygen Saturation
时间窗: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
The patients were monitored with a pulse oximetry device in the operating room and their oxygen saturation % (spO2) was recorded.
Heart Rate
时间窗: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
Patients were monitored with a three-lead ECG in the operating room and their heart rates were recorded as beats per minute. (.../min)
Blood Pressure
时间窗: 5 minutes and 10 minutes after direct laryngoscopy and endotracheal intubation
The patients were monitored in the operating room by wearing a noninvasive blood pressure cuff and measurements were taken at 5-minute intervals. Systolic blood pressure, diastolic blood pressure and mean arterial pressure were recorded in mmHg.
次要结局
未报告次要终点
研究者
Emine Atlı
MD, Anesthesiology and Reanimation
Derince Training and Research Hospital