Impact of Dietary Nitrate on Erectile Dysfunction
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- The changes of erectile function according to the international index of erectile function (IIEF5) score
研究概览
简要总结
An expanding number of studies suggest a therapeutic role for nitrate and nitrite, most notably in treatment and prevention of cardiovascular disease including ischemia-reperfusion injury and hypertension. The nutritional aspects of these cardioprotective effects are particularly intriguing since nitrate is abundant in our everyday diet. Nitrate improves vascular functions in old adults and improves ischemia reperfusion injury in experimental models.
Whether dietary nitrate improves erectile dysfunction is not known and will be investigated in the present study.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Basic Science
- 盲法
- Double (Participant, Investigator)
盲法说明
Double blinded and randomised
入排标准
- 年龄范围
- 30 Years 至 80 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patients with erectile Dysfunction (IIEF5: 8-21) PDE-5 Inhibitors Responder Aged 30-80 years
排除标准
- •Spinal cord disease
- •Insulin dependent Diabetes mellitus
- •Prostate cancer after operation, radiotherapy and hormone therapy
- •Treatment with NO-Donators or sGC-Activators
- •Chronic kidney disease (Stage IV-V)
- •Advanced liver dysfunction
结局指标
主要结局
The changes of erectile function according to the international index of erectile function (IIEF5) score
时间窗: 4 Weeks
Erectile dysfunction improvement as measured by IIEF5 score (range 5-25)
次要结局
- Change in oral microbiome(4 Weeks)
- Change in cardiac diastolic function,(4 weeks)
研究者
Fadi Al-Rashid
MD, Principal Investigator
University Hospital, Essen