Aldosterone-induced microvascular dysfunction as a cause of salt-sensitivity in obesity? - Aldosterone, microvascular function and salt-sensitivity

Medisch Universitair Ziekenhuis Maastricht0 个研究点目标入组 40 人开始时间: 待定最近更新: 2024年4月23日

适应症

试验速览

暂无简介。

•Obese individuals
•- Age 18-65 years
•- Caucasian (because of ethnic differences in microvascular function and in the prevalence of cardiovascular disease and associated risk factors)
•- Waist circumference > 102 cm (men)/> 88 cm (women) ;Lean individuals
•- Age 18-65 years
•- Caucasian (because of ethnic differences in microvascular function and in the prevalence of cardiovascular disease and associated risk factors)
•- Waist circumference < 94 cm (men)/< 80 cm (women)

•- Cardiovascular disease (stroke, coronary artery disease, peripheral vascular disease, congestive heart failure, cardiac shunts, cardiac surgery, pulmonary hypertension, cardiac arrhythmias, family history of cardiac arrhythmias or sudden cardiac death)
•- Diabetes mellitus/impaired glucose metabolism (fasting glucose values > 6.1 mmol/L), because not only diabetes, but also intermediate hyperglycaemia has been associated with microvascular disease, which impedes the distinction between cause and consequence of disturbances in glucose metabolism in the concerning individuals
•- Stage 3 hypertension (blood pressure > 180/110 mm Hg) in order not to expose these persons to unnecessary risks
•- Unstable or severe pulmonary disease
•- Unstable or severe thyroid disorders
•- Inflammatory diseases
•- Smoking (due to impairment of microvascular function)
•- Alcohol use > 2 U/day (women)/> 3 U/day (men)
•- Use of glucose-lowering medications, because of interference with microvascular function
•- Use of corticosteroids (might cause hypertension and interfere with electrolyte homeostasis and glucose metabolism) and regular use (weekly or several times a week) of NSAIDs (might cause disturbance of microvascular function and electrolyte excretion)
•- eGFR < 60 mL/min
•- Impairment of hepatic function
•- Pregnancy or lactation

发起方

Medisch Universitair Ziekenhuis Maastricht