A retrospective cross-sectional cohort trial assessing the implications of MTHFR polymorphisms on DNA methylation and platinum resistance in ovarian cancer patients

The results of this trial revealed strong associations between dietary B6, B12, zinc and folate intakes in heterozygous A1298C and C677T carriers and platinum response. There is also an association between serum folate, homocysteine, dietary zinc, B12 intakes and platinum sensitivity in participants without a mutation. Further research is required to understand the direction the association flows in order to be able to provide any sound nutritional recommendations, however this study provides a foundation for future research on the role of diet on platinum response in epithelial ovarian cancer patients in relation to MTHFR polymorphisms. Furthermore, the high prevalence of MTHFR mutations in this population may require further investigation into the role of these polymorphisms in the development and/or progression of ovarian cancer. These results require studies on a larger group of participants to confirm the findings shown here.