T2 Biomarkers Predictive Value in Occupational Asthma After Cessation of Exposure.
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 入组人数
- 38
- 试验地点
- 2
- 主要终点
- Remission of occupational asthma
研究概览
简要总结
Occupational exposure is known to cause 15% of asthma cases. The main treatment for occupational asthma is to stop exposure if possible. Although, remission of occupational asthma only occurs in only 30 % of patients after cessation of exposure. There is currently no way of predicting which patients will go into remission after cessation of exposure.
In non-occupational asthma, the inflammatory biomarker T2 has allowed the entry into personalized medicine and can predict future exacerbations.
The investigators hypothesize that T2 biomarkers could be predictive markers for remission in occupational asthma after exposure cessation.
The investigators intend to carry out a follow-up study at the University Hospital of Strasbourg to perform the non-specific bronchial hyperresponsiveness test to assess remission in patients diagnosed with occupational asthma and to compare baseline T2 biomarkers in remission and non remission patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age over 18
- •Diagnosis of occupational asthma by specific inhalation challenge
- •Exposure to sensitizing agent avoided or reduced
- •Able to understand the aims and risks of the research and to give free and informed consent
- •For women of childbearing age: effective contraception in progress.
- •Benefiting from social security coverage
排除标准
- •Impossibility of giving the subject informed information (subject in emergency situation, difficulties in understanding the subject)
- •Subject under court protection
- •Subject under guardianship or curatorship
- •Pregnant or breast-feeding patient
研究组 & 干预措施
patients with occupational asthma
干预措施: Measure of T2 biomarkers (Other)
结局指标
主要结局
Remission of occupational asthma
时间窗: Day 1
Remission of occupational asthma is defined by absence of nonspecific bronchial hyperresponsiveness. Assessment of nonspecific bronchial hyperresponsiveness is realized by metacholine challenge
Comparison of TH2-type inflammation levels
时间窗: Day 1
To compare the level of Th2-type inflammation in sputum from patients in remission versus patients with persistent asthma.
次要结局
- Remission of occupational rhinitis(Day 1)