Second Affiliated Hosptial， School of Medicine, ZheJiang University
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 40
- 试验地点
- 1
- 主要终点
- Incidence of hypotension
研究概览
简要总结
The goal of this clinical trial is to determine the ED50 and ED95 of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients undergoing major abdominal surgery using up-and-down sequential method . The main question it aims to answer is:
What is the effective concentration of prophylactic norepinephrine infusion for preventing post-induction hypotension in elderly patients.
Participants will receive different concentrations of norepinephrine infusion at the beginning of anesthesia induction until 15 minutes after intubation.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 65 Years 至 80 Years（Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •aged 65 to 80 years
- •Undergoing major abdominal surgery
- •American Society of Anesthesiologists (ASA) physical status of I/II/III
排除标准
- •Patient refusal
- •Severe untreated or uncontrolled hypertension despite medications
- •Bradycardia (heart rate < 50 beat per minute)
- •Cardiac morbidities, heart block greater than the first degree
- •Severe hepatic and renal dysfunction
- •hyperthyroidism
- •vascular diseases
- •Monoamine oxidase inhibitors were used 2 weeks before surgery
研究组 & 干预措施
Norepinephrine
干预措施: norepinephrine bitartrate (Drug)
结局指标
主要结局
Incidence of hypotension
时间窗: 15 minutes after intubation
less than 80% baseline blood pressure less than 80% baseline blood pressure less than 80% baseline blood pressure
次要结局
- incidence of reactive hypertension(15 minutes after intubation)
- incidence of bradycardia(15 minutes after intubation)