Investigating the acute effects of THC on functional brain systems - THC-phMRI

niversity Medical Center Utrecht0 个研究点开始时间: 2007年1月19日最近更新: 2012年3月19日

适应症

试验速览

暂无简介。

•History of mild cannabis use for at least one year (<1/week and = 4/year)
•History without psychotic experiences after cannabis use
•Age between 18 and 45 years
•Right-handedness, assessed with the Edinburgh Handedness Inventory (Oldfield, 1971
•Written informed consent of the subject
•Are the trial subjects under 18? no
•Number of subjects for this age range:
•F.1.2 Adults (18-64 years) yes
•F.1.2.1 Number of subjects for this age range
•F.1.3 Elderly (>=65 years) no
•F.1.3.1 Number of subjects for this age range

•Any clinical significant abnormality of any clinical laboratory test, including urinary drug screening
•Impaired physical health evaluated by medical history, physical (including neurological) examination and screening laboratory tests (see paragraph 8.3.1)
•History of clinically significant psychiatric or neurological illness
•History of clinically significant psychiatric or neurological illness in first- or second-degree relatives
•History of alcohol and/or drug abuse (DSM-IV criteria)
•Body Mass Index (B.M.I.) between 18 and 28 kg/m2
•Paranoid ideation or psychoticism on SCL-90
•Any subject who received any investigational medication within 90 days prior to the start of the study or who is scheduled to receive an investigational drug
•The use of any medication within three weeks prior to the start of the study, except for paracetamol
•Positive HIV or Hepatitis B/C test
•Blood donation within 3 months before the start of the study
•Claustrophobia
•Metal objects in or around the body (braces, pacemaker, metal fragments)

发起方