NCT00889031已完成不适用
Protocol to Obtain Blood Samples for Leukemia Research
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 187
- 试验地点
- 1
- 主要终点
- To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis.
研究概览
简要总结
The purpose of this study is to collect a blood sample in patients with Chronic Lymphocytic Leukemia (CLL).
详细描述
The blood sample will be used in the laboratory to perform studies focusing on Chronic Lymphocytic Leukemia (CLL).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients undergoing routine blood draws as part of their ongoing follow-up for Chronic Lymphocytic Leukemia (CLL) at the Norris Cotton Cancer Center of DHMC.
排除标准
- •Patients who have received cytotoxic drug, oral or intravenous steroid or targeted antibody therapy for CLL or other disease process within the past 6 months are excluded. Use of intravenous immunoglobulin (IVIg) is not a reason for exclusion.
结局指标
主要结局
To determine the frequency with which CLL cells incubated ex vivo with vincristine undergo rapid interphase apoptosis.
时间窗: 2 Years
次要结局
- To determine whether suppression or inhibition of BCL2 family members can acutely sensitize CLL cells to vincristine.(2 Years)
研究者
Christopher H. Lowrey
Professor of Medicine and of Pharmacology and Toxicology
Dartmouth-Hitchcock Medical Center
研究点 (1)
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